Liverpool can take another giant step towards just a second English top-flight title in 35 years against fragile Manchester City on Sunday as Ruben Amorim aims for a first Premier League win as Manchester United manager.
The top-of-the-table clash at Anfield offers Arsenal, who face West Ham, and Chelsea, who host Aston Villa, the chance to gain ground.
AFP Sport picks out some of the key talking points ahead of this weekend’s action:
Liverpool’s league to lose?
Arne Slot’s rampant Reds go into the weekend off the high of beating Real Madrid 2-0 to top the Champions League table.
Liverpool have barely put a foot wrong in the Premier League either, surging into an eight-point lead after just 12 games.
All three teams who have enjoyed a lead of eight points or more at this stage of the season in Premier League history have gone on to win the title.
City are there for the taking.